01 - Whisk together buttermilk, hot sauce, salt, and pepper in a large bowl. Add chicken pieces and turn to coat thoroughly. Cover and refrigerate for at least 4 hours or overnight for optimal tenderness.
02 - Combine flour, paprika, garlic powder, onion powder, cayenne pepper, salt, and black pepper in a large shallow dish. Mix well to distribute spices evenly.
03 - Remove chicken from marinade, allowing excess buttermilk to drip off without patting dry. Press each piece firmly into seasoned flour, turning to coat completely. Transfer coated pieces to a wire rack.
04 - Pour oil into a large heavy skillet or deep fryer. Heat to 350°F, maintaining temperature throughout frying process.
05 - Carefully place chicken pieces in hot oil in batches, avoiding overcrowding. Fry for 8-12 minutes per side, turning once, until golden brown and crispy. Verify internal temperature reaches 165°F.
06 - Transfer fried chicken to a clean wire rack or paper towels to drain. Let rest for 5 minutes before serving to allow juices to redistribute.